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Drug Interactions With 5-Hydroxytryptophan

5-Hydroxytryptophan Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when 5-hydroxytryptophan is combined with any of the drugs listed above.
Antidepressants
Taking 5-hydroxytryptophan with prescription antidepressants can cause a group of dangerous symptoms called serotonin syndrome, which include symptoms such as confusion, hallucinations, a fast heartbeat, feeling faint, fever, sweating, muscle spasms, difficulty walking, and diarrhea. Talk to your healthcare provider before taking these depression medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
Meperidine (Demerol)
Taking meperidine with 5-hydroxytryptophan may increase the risk of serotonin syndrome. Do not combine meperidine with 5-hydroxytryptophan without your healthcare provider's approval.
Monoamine Oxidase Inhibitors (MAOIs)
Taking 5-hydroxytryptophan and an MAOI together can cause life-threatening side effects. Never take an MAOI and 5-hydroxytryptophan together.
St. John's Wort
Taking 5-hydroxytryptophan with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
Tramadol (Rybix ODT, Ryzolt, Ultram, Ultram ER) or Tramadol and Acetaminophen (Ultracet)
Taking 5-hydroxytryptophan with tramadol can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
Last reviewed by: Kristi Monson, PharmD
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