Drug Interactions With Apri

Barbiturates, antibiotics, and protease inhibitors may interact with Apri. Drug interactions such as these can interfere with the effectiveness of Apri, increasing your risk of pregnancy. Some of these drug interactions with Apri can also increase your risk of developing side effects. Prior to taking Apri, be sure to tell your healthcare provider about any other medications you are taking.

An Introduction to Drug Interactions With Apri

Apri® (desogestrel/ethinyl estradiol) is an oral contraceptive and is a generic version of Desogen®. Apri can potentially interact with several other medicines. Many of these interactions can be severe enough to cause accidental pregnancy, and a backup method of birth control may be recommended to avoid pregnancy. Some of the medicines that may lead to Apri interactions include:
  • Aminoglutethimide (Cytadren®)
  • Antibiotics
  • Aprepitant (Emend®)
  • Atorvastatin (Lipitor®) or combination medications that contain atorvastatin (Caduet®, Liptruzet™)
  • Barbiturate medications, including (but not limited to):
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
Last reviewed by: Kristi Monson, PharmD
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