Botox Drug Interactions

If certain medications are combined with Botox, drug interaction may occur. These interactions can increase your risk of side effects, increase the effectiveness of Botox, and have other interactions that are currently unknown. Aminoglycoside antibiotics and neuromuscular-blocking medications are just two of the medicines that are known to cause Botox drug interactions.

 

An Introduction to Botox Drug Interactions

Botox® (botulinum toxin type A) can potentially interact with a few other medicines. Some of the medications that may lead to Botox drug interactions include:
 
  • Aminoglycoside antibiotics, such as:
     
    • Amikacin (Amikin®)
    • Gentamicin
    • Kanamycin (Kantrex®)
    • Neomycin (Neo-Fradin®)
    • Streptomycin
    • Tobramycin
 
  • Botulinum toxin type B (Myobloc®)
     
  • Neuromuscular-blocking medications, such as:
     
    • Atracurium
    • Cisatracurium (Nimbex®)
    • Doxacurium (Nuromax®)
    • Mivacurium (Mivacron®)
    • Pancuronium
    • Rocuronium (Zemuron®)
    • Succinylcholine (Anectine®, Quelicin®)
    • Tubocurarine
    • Vecuronium (Norcuron®).
 

Botox Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Botox is combined with any of the drugs listed above.
 
Aminoglycoside Antibiotics
Taking Botox and an aminoglycoside antibiotic together may increase the nerve-blocking effects of Botox, perhaps increasing your risk of Botox side effects. Talk with your healthcare provider before using these medications together.
(Botox Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;