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Conjugated Estrogens Vaginal Cream

Conjugated estrogens vaginal cream is commonly prescribed to treat vaginal problems that occur in postmenopausal women, such as vaginal dryness, itching, and burning, by replacing the estrogen that the ovaries no longer produce. The cream is typically used cyclically (three weeks on and one week off). Possible side effects of conjugated estrogens vaginal cream include breast tenderness, nausea, and headaches.

What Is Conjugated Estrogens Vaginal Cream?

Conjugated estrogens vaginal cream (Premarin® Vaginal Cream) is a prescription medication that contains a mixture of natural estrogen hormones. It is inserted vaginally using a special applicator. The cream is used to treat dryness, itching, and burning in and around the vagina, usually in postmenopausal women.
(Click What Is Conjugated Estrogens Vaginal Cream Used For? for more information, including possible off-label uses.)

Conjugated Estrogens Vaginal Cream Side Effects

As with any medicine, side effects can occur with conjugated estrogens vaginal cream. However, not everyone who uses it will experience side effects. In fact, most women tolerate the cream quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are easily treated by you or your healthcare provider. Serious side effects are less common.
Common side effects of conjugated estrogens vaginal cream include but are not limited to:
  • Headaches
  • Breast tenderness
  • Irregular vaginal bleeding or spotting
  • Abdominal (stomach) cramps or bloating
  • Nausea and vomiting.
(Click Side Effects of Conjugated Estrogens Vaginal Cream to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Last reviewed by: Kristi Monson, PharmD
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