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Drug Interactions With Conjugated Estrogens Vaginal Cream

More Information on Interactions With Conjugated Estrogens Vaginal Cream

The following sections explain in detail the potentially negative interactions that can occur when conjugated estrogens vaginal cream is combined with any of the drugs listed above.
Barbiturate Medications
Barbiturates may cause your body to metabolize the hormones in conjugated estrogens vaginal cream too quickly, possibly leading to low levels of these hormones in the body. Because the cream acts directly on the vaginal tissues and is absorbed into the bloodstream without passing through the liver first (as happens with oral medications), this interaction is probably not significant.
Certain Antibiotics or Antifungals
Some antibiotic or antifungal medications may decrease the ability of your body to metabolize the hormones in conjugated estrogens vaginal cream, possibly leading to high levels of these hormones in the body. This may increase the risk of side effects of conjugated estrogens vaginal cream. Check with your healthcare provider before combining conjugated estrogens vaginal cream with certain antibiotics or antifungals.
Certain Seizure Medications
Some seizure medications may cause your body to metabolize the hormones in conjugated estrogens vaginal cream too quickly, possibly leading to low levels of these hormones in the body. Because the cream acts directly on the vaginal tissues and is absorbed into the bloodstream without passing through the liver first (as happens with oral medications), this interaction is probably not significant.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Conjugated estrogens vaginal cream may increase the level of cyclosporine in your blood, possibly increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower cyclosporine dose, or you may need to switch to an alternate medication.
Last reviewed by: Kristi Monson, PharmD
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