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Drug Interactions With Conjugated Estrogens Vaginal Cream

If certain substances are combined with conjugated estrogens vaginal cream, drug interactions may occur. Some of the medications that could cause negative interactions include certain antibiotics, seizure medications, and protease inhibitors. Some of these drug interactions with conjugated estrogens vaginal cream may cause your body to metabolize the medications too quickly or not quickly enough, possibly leading to side effects or other problems.

An Introduction to Drug Interactions With Conjugated Estrogens Vaginal Cream

Conjugated estrogens vaginal cream (Premarin® Vaginal Cream) can potentially interact with numerous other medicines. Some of the medicines that may lead to drug interactions with conjugated estrogens vaginal cream include:
  • Barbiturates, such as:
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
  • Certain antibiotics or antifungals, such as:
    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)
  • Certain seizure medications, such as:
  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
  • St. John's wort (Hypericum perforatum)
  • Thyroid medications, such as:
Last reviewed by: Kristi Monson, PharmD
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