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Side Effects of Conjugated Estrogens Vaginal Cream

Common Side Effects of Conjugated Estrogens Vaginal Cream

Some women assume that conjugated estrogens vaginal cream can only cause vaginal side effects. However, because a significant amount of the hormones in the cream is absorbed into the bloodstream, any of the usual side effects of estrogen can occur with conjugated estrogens vaginal cream. Common side effects of estrogen medications include:
  • Headaches
  • Breast tenderness
  • Irregular vaginal bleeding or spotting
  • Abdominal (stomach) cramps or bloating
  • Nausea and vomiting
  • Hair loss
  • High blood pressure
  • High blood sugar (hyperglycemia)
  • Fluid retention
  • Enlargement of benign tumors of the uterus (uterine fibroids)
  • Vaginal yeast infections.
In addition to the usual estrogen side effects, conjugated estrogens vaginal cream can cause local vaginal reactions, burning, irritation, and itching.

Final Thoughts on Side Effects of Conjugated Estrogens Vaginal Cream

You may experience some or none of the side effects of conjugated estrogens vaginal cream listed in this article. Unfortunately, it can be difficult to tell whether any particular side effect (such as nausea) is caused by conjugated estrogens vaginal cream or other factors. Therefore, make sure to let your healthcare provider know if you develop any side effects while using the cream or if something "just does not seem right." While it may not be a side effect, your healthcare provider will be able to diagnose and treat the problem.
Last reviewed by: Kristi Monson, PharmD
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