Side Effects of Conjugated Estrogens Vaginal Cream

Although most women have no problems with conjugated estrogens vaginal cream, side effects are possible -- some of which can be quite serious. Notify your healthcare provider if you experience coughing up blood, chest pain, or signs of an allergic reaction. In most cases, however, side effects of conjugated estrogens vaginal cream are minor and easily treated. Common side effects include headaches, breast tenderness, and nausea.

An Introduction to Side Effects of Conjugated Estrogens Vaginal Cream

As with any medicine, side effects are possible with conjugated estrogens vaginal cream (Premarin® Vaginal Cream). However, not everyone who uses the cream will experience side effects. In fact, most women tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with conjugated estrogens vaginal cream. Your healthcare provider can discuss a more complete list of side effects with you.)

Serious Side Effects of Conjugated Estrogens Vaginal Cream

Some side effects of estrogen medications (including conjugated estrogens vaginal cream) are rare, but are serious enough to mention. These side effects include:
Because of the serious nature of these side effects, there are a few symptoms you should watch out for and report to your healthcare provider immediately if they occur. These include but are not limited to:
  • Signs of a blood clot in the leg, such as:
    • Pain in the calf
    • Leg cramps
    • Leg or foot swelling
  • Signs of a blood clot in the lung, such as:
    • Shortness of breath
    • Sharp chest pain
    • Coughing up blood
    • Vision or speech changes
    • Weakness or numbness in an arm or leg
    • Severe headache
  • Signs of liver damage, such as:
    • Yellowing of the whites of the eyes or skin (jaundice)
    • Dark urine
    • Upper-right abdominal pain (stomach pain)
  • Migraines (or changes in your migraines, if you have had them before)
  • Breast lumps
  • Chest pain or heaviness, which may be signs of a heart attack
  • Sudden loss of vision or vision changes, which can be a sign of a blood clot in the eye
  • Heavy vaginal bleeding or unexpected vaginal bleeding
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling
    • Wheezing
    • Difficulty breathing or swallowing.
Last reviewed by: Kristi Monson, PharmD
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