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What Is Conjugated Estrogens Vaginal Cream Used For?

Conjugated estrogens vaginal cream is used for treating vaginal dryness, burning, and itching in postmenopausal women. These symptoms are typically caused by thinning of the vaginal tissues due to low estrogen levels after menopause. Conjugated estrogens vaginal cream is ideal for women whose primary menopause symptoms are vaginal. At this time, there are no off-label conjugated estrogens vaginal cream uses.

What Is Conjugated Estrogens Vaginal Cream Used For? -- An Overview

Conjugated estrogens vaginal cream (Premarin® Vaginal Cream) is a prescription hormone replacement medication that contains a mixture of natural estrogens. It does not, however, contain any progesterone hormones. Conjugated estrogens vaginal cream is approved to treat vaginal inflammation caused by thinning of the vaginal tissues, usually the result of low estrogen levels after menopause.

Why Is Conjugated Estrogens Vaginal Cream Used for Vaginal Symptoms?

Menopause is a normal change in a woman's life when she stops having her period. That's why some people call menopause "the change of life." A woman has reached menopause when she has not had a period for 12 months in a row and there are no other causes for this change. Menopause symptoms can affect the entire body, including the vagina. Vaginal menopause symptoms include:
  • Dryness
  • Burning or other pain
  • Itching.
These symptoms occur due to low estrogen levels after menopause. Because conjugated estrogens vaginal cream replaces some of the estrogen lost during menopause, it not only helps relieve these vaginal symptoms, it also can reduce vaginal thinning that occurs.
When used to treat menopause, conjugated estrogens vaginal cream should be used at the lowest effective dose for the shortest period necessary. The cream is ideal for women whose primary menopause symptoms are vaginal problems, as using the cream (instead of taking the hormones by mouth) exposes the body to less of the hormones. However, a significant amount of the estrogens in conjugated estrogens vaginal cream are absorbed into the bloodstream, and it is expected that many of the problems seen with oral hormone replacement therapy also apply to vaginal hormone replacement therapy (see Precautions and Warnings With Conjugated Estrogens Vaginal Cream).
Last reviewed by: Kristi Monson, PharmD
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