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Drug Interactions With the Copper IUD

It is unknown if the copper IUD (ParaGard®) interacts with medications. This intrauterine device (IUD) does not contain any hormones. Although it is regulated as a drug by the United States Food and Drug Administration (FDA), many people do not consider it to be a drug.
There are no well-established copper IUD drug interactions at this time. There have been a few reports of failure with the copper IUD (resulting in pregnancy) in women receiving azathioprine (Imuran®, Azasan®), an immunosuppressant medication. It has been suggested that immunosuppressant drugs may interfere with the way the copper IUD works. However, this problem has been reported very rarely, and it is unclear if this is an actual interaction with the copper IUD.
Also, the possibility of rare or minor interactions cannot be entirely ruled out. As a result, it is always a good idea to mention the copper IUD whenever discussing your medications or medical devices with your healthcare provider.
Last reviewed by: Kristi Monson, PharmD
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