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Demulen Drug Interactions

Cyclosporine (Gengraf, Neoral, Sandimmune)
Demulen may increase the level of cyclosporine in your blood, possibly increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower dose of cyclosporine, or you may need to switch to a different method of contraception.
Modafinil (Provigil)
Modafinil can make Demulen less effective, potentially increasing your risk of pregnancy. Talk with your healthcare provider, as you may need to use a backup method of contraception.
Protease Inhibitors
Using Demulen with a protease inhibitor may increase your risk of pregnancy and can make the protease inhibitor less effective. Talk with your healthcare provider before combining these medications.
Selegiline (Eldepryl, Emsam, Zelapar)
The hormones in Demulen may increase the level of selegiline in your blood, possibly increasing your risk of side effects. Your healthcare provider may need to lower your selegiline dosage or may recommend an alternate form of contraception.
Some Seizure Medications
Some seizure medications may cause your body to metabolize the hormones in Demulen too quickly, possibly increasing your risk of pregnancy. Ask your healthcare provider if you should use a different method of contraception while taking a seizure medication.
St. John's Wort
St. John's wort (a commonly used herbal supplement) may decrease the effectiveness of Demulen, possibly increasing the chance of pregnancy. In general, you should not take St. John's wort while using Demulen.

Final Thoughts

It is possible that not all drug interactions with Demulen were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
Last reviewed by: Kristi Monson, PharmD
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