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Demulen Side Effects

Side Effects to Report

Some side effects with Demulen, while occurring infrequently, are potentially serious and should be reported to your healthcare provider. Demulen 1/50 (but not Demulen 1/35) contains a high dose of estrogen. As a result, it may have a higher risk of many of the serious side effects of birth control pills. These serious problems include but are not limited to:
  • Signs of a blood clot in the leg, such as:
    • Pain in the calf
    • Leg cramps
    • Leg or foot swelling
  • Signs of a blood clot in the lung, such as:
    • Shortness of breath
    • Sharp chest pain
    • Coughing up blood
  • Sudden loss of vision or vision changes, which can be a sign of a blood clot in the eye
  • Heavy vaginal bleeding between periods (light bleeding or spotting is normal)
  • High blood pressure (hypertension)
  • Signs of a stroke, such as:
    • Vision or speech changes
    • Weakness or numbness in an arm or leg
    • Severe headache
  • Signs of liver damage, such as:
    • Yellowing of the whites of the eyes or skin (jaundice)
    • Dark urine
    • Upper-right abdominal (stomach) pain
  • Depression or other emotional changes
  • Chest pain or heaviness, which may be signs of a heart attack
  • Rapid weight gain or swelling in the hands or feet, which may be a sign of severe fluid retention
  • High cholesterol
  • Migraines (or changes in your migraines, if you have had them before)
  • Breast lumps
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling
    • Wheezing
    • Difficulty breathing or swallowing.
Last reviewed by: Kristi Monson, PharmD
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