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Depo-SubQ Provera 104 Drug Interactions

CYP 3A4 Inducer Medications
The liver breaks down the hormones in depo-subQ Provera 104 using enzymes known as CYP 3A4 enzymes. Certain medications known as CYP 3A4 inducers can increase the activity of these enzymes. Combining depo-subQ Provera 104 with one of these CYP 3A4 inducers may decrease the level of depo-subQ Provera 104 in your bloodstream, possibly making it less effective.
If you are using depo-subQ Provera 104 as a contraceptive, talk to your healthcare provider about this interaction. You may need to use a different birth control method.
Griseofulvin
Griseofulvin may decrease the effectiveness of combination birth control pills (pills that contain estrogen and progestin). Although it is unknown if griseofulvin also affects depo-subQ Provera 104, you may want to use another form of birth control if you are taking griseofulvin and also receiving depo-subQ Provera 104 injections.
Protease Inhibitors
Protease inhibitors can increase or decrease the level of depo-subQ Provera 104 in the bloodstream, which could increase the risk for side effects or make the medication less effective. Check with your healthcare provider before combining depo-subQ Provera 104 with a protease inhibitor.
Retinoids
Retinoids may decrease the effectiveness of progestin-only birth control pills. It is unknown if retinoids affect depo-subQ Provera 104 in the same way. If you are using depo-subQ Provera 104 as a form of contraception, talk to your healthcare provider about this potential interaction. You may need to use a different birth control method.
Tranexamic Acid
Both tranexamic acid and hormonal contraceptives, including depo-subQ Provera 104, can increase the risk for blood clots. Taking these medications together may increase this risk even more than using either medicine alone. Talk to your healthcare provider about this potential interaction before taking these medications together.
Last reviewed by: Kristi Monson, PharmD
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