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Depo-SubQ Provera 104

How Does Depo-SubQ Provera 104 Work?

depo-subQ Provera 104 contains medroxyprogesterone, a synthetic form of the female hormone progesterone. depo-subQ Provera 104 prevents pregnancy by stopping ovulation (the release of an egg from the ovary). It also thins the endometrium (the lining of the uterus), preventing implantation (attachment of a fertilized egg to the wall of the uterus), and thickens the cervical mucus, making it more difficult for sperm to reach the egg.
For relieving pain caused by endometriosis, depo-subQ Provera 104 works by reducing estrogen levels in the body. Estrogen is responsible for the thickening of the uterine lining. Without estrogen, the endometrial growths shrink, which reduces the pain and symptoms of the condition. depo-subQ Provera 104 does not cure endometriosis; the growths will return if the medicine is stopped.

When and How to Receive It

Some general considerations to keep in mind during treatment with depo-subQ Provera 104 include the following:
  • This medication is given as a subcutaneous injection (an injection into the tissue just below the skin) every 12 to 14 weeks.
  • The shot is usually given just under the skin on the thigh or abdomen (stomach).
  • The injection will usually be given by a healthcare provider in an office or clinic.
  • depo-subQ Provera 104 should not be used for longer than two years, unless absolutely necessary.
  • For this drug to work properly, it must be used as prescribed. Make sure to keep all of your appointments with your healthcare provider to avoid missing a dose.

Dosing Information

There is only one standard dosage of this medication, regardless of your weight, other medical conditions, or the reason you are using it.
As is always the case, do not adjust your dose unless your healthcare provider specifically tells you to do so.
(Click depo-subQ Provera 104 Dosage for more information.)
Last reviewed by: Kristi Monson, PharmD
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