Depo-SubQ Provera 104 Side Effects

Clinical studies have shown that headaches, vaginal bleeding between periods, and weight gain are some of the most common side effects of depo-subQ Provera 104. Most reactions to this drug tend to be minor and easy to treat. However, it is important to recognize some of the more serious problems that require immediate medical attention, such as seizures, vision or speech changes, or coughing up blood.

An Introduction to Depo-SubQ Provera 104 Side Effects

Just like any medicine, depo-subQ Provera 104® (medroxyprogesterone subcutaneous injection) can cause side effects. However, not everyone who uses the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible depo-subQ Provera 104 side effects. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of Depo-SubQ Provera 104

depo-subQ Provera 104 has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people receiving depo-subQ Provera 104 were carefully documented. As a result, it was possible to see what side effects occurred and how often they appeared.
In these studies, common side effects of depo-subQ Provera 104 included:
  • Headache -- in up to 9 percent of people
  • Vaginal bleeding between periods -- up to 7 percent
  • Weight gain -- up to 6 percent
  • Lack of a menstrual period (amenorrhea) -- up to 6 percent
  • Skin reactions at the site of the injection -- up to 5 percent.
Other common side effects, occurring in 1 to 5 percent of people, included:

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Last reviewed by: Kristi Monson, PharmD
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