Depo-SubQ Provera 104 Uses

If you want to prevent pregnancy, a healthcare provider may prescribe depo-subQ Provera 104. This prescription medicine contains a synthetic form of progesterone and prevents pregnancy by stopping ovulation, thickening the cervical mucus, and thinning the lining of the uterus. depo-subQ Provera 104 is also used to relieve pain caused by endometriosis. Possible off-label uses include relieving symptoms from menopause or certain types of cancer.

What Is Depo-SubQ Provera 104 Used For?

depo-subQ Provera 104® (medroxyprogesterone subcutaneous injection) is a prescription medication approved to prevent pregnancy and to manage pain caused by endometriosis. This product contains medroxyprogesterone, a progestin hormone. It is given as a subcutaneous (below the skin) injection every three months.

Using Depo-SubQ Provera 104 to Prevent Pregnancy

depo-subQ Provera 104 is an injectable form of hormonal birth control. It offers an alternative to birth control pills (oral contraceptives).
depo-subQ Provera 104 is similar to Depo-Provera® (medroxyprogesterone intramuscular injection), which is sometimes called "the birth control shot." Both medicines are long-acting injectable forms of birth control, and both contain the hormone medroxyprogesterone. However, depo-subQ Provera 104 is injected in the layer of tissue just below the skin (a subcutaneous, or subQ, injection), while Depo-Provera is injected into the muscle (an intramuscular, or IM, injection). In addition, Depo-Provera contains higher doses of medroxyprogesterone.
depo-subQ Provera 104 offers some advantages over oral birth control pills. Some of these advantages include the following:
  • depo-subQ Provera 104 is a long-acting drug. Each shot helps to prevent pregnancy for three months.
  • There are no daily pills to remember to take.
  • It is discrete -- the shots are given in the privacy of your healthcare provider's office.
In addition, depo-subQ Provera 104 does not contain estrogen hormones. This makes it a good choice for women who should not use estrogen, including women who have just given birth or who are breastfeeding (see Breastfeeding and Birth Control for more information about birth control options for breastfeeding women).
depo-subQ Provera 104 also has some disadvantages to consider. Possible disadvantages include the following:
  • It can cause side effects that may be bothersome for some women (see depo-subQ Provera 104 Side Effects).
  • Bothersome side effects may persist until the medicine is eliminated from the body, which can take several months.
  • It is not recommended for long-term use (more than two years).
  • It requires regular visits to your healthcare provider to receive the shot.
  • If you want to become pregnant, you will have to wait until your last shot has worn off. In many cases, it can take a year or longer after the last shot to become pregnant.
In addition, it is important to know that depo-subQ Provera 104 does not protect against HIV or other sexually transmitted diseases (STDs). In many situations, it is advisable to use condoms in addition to depo-subQ Provera 104 to prevent the transmission of STDs.
Last reviewed by: Kristi Monson, PharmD
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