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Diethylpropion Dosing

The recommended dose of diethylpropion for the short-acting tablets is 25 mg three times a day, taken an hour before meals. If needed, your healthcare provider may suggest taking an additional evening dose to control nighttime hunger. For the long-acting form of diethylpropion, dosing typically starts at 75 mg once daily, taken in the mid-morning.

Diethylpropion Dosing: An Introduction

The dose of diethylpropion hydrochloride (Tenuate®) that your healthcare provider prescribes will vary, depending on a number of factors, including:
  • Whether you are taking short-acting or long-acting diethylpropion tablets
  • Other medical conditions you may have
  • Other medications you may be currently taking.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.

Diethylpropion Dosing for Weight Loss

With the short-acting tablets, the recommended dose of diethylpropion for weight loss is 25 mg three times daily, taken one hour before meals. If necessary, your healthcare provider may recommend taking an additional evening dose to help control nighttime hunger. With long-acting tablets, the recommended dose is diethylpropion 75 mg (one extended-release tablet), taken once a day in mid-morning.
Diethylpropion is intended for short-term use only (just a few weeks). Longer use is unlikely to be effective, since the body adjusts to the appetite-suppressing properties of the medication. Also, the drug has the potential to be abused (which is another reason why diethylpropion use should be limited to just a few weeks).

General Information on Dosing With Diethylpropion

Considerations for people taking diethylpropion include the following:
  • The medication comes in short-acting and long-acting tablet forms. The short-acting tablets are taken three times a day, one hour before meals, while the long-acting tablets are taken just once a day in the mid-morning.
  • The long-acting tablets must be swallowed whole; do not break, chew, or crush them.
  • Diethylpropion should be combined with an appropriate diet. It is not meant to be used without dieting.
  • Do not take the medication more often or at higher doses than prescribed, as this can lead to addiction or dependence.
  • For the medication to work properly, it must be taken as prescribed.
  • If you are unsure about anything related to diethylpropion dosing, talk to your doctor, nurse, or pharmacist.
Last reviewed by: Kristi Monson, PharmD
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