Precautions and Warnings With Diethylpropion

Specific Precautions and Warnings With Diethylpropion

Warnings and precautions to be aware of prior to taking diethylpropion include the following:
  • In rare cases, the medication can cause a serious lung problem known as primary pulmonary hypertension (PPH). Let your healthcare provider know if you have any symptoms of PPH, such as:
    • Difficulty breathing
    • Chest pain
    • Fatigue or weakness
    • Dizziness or fainting
    • Swelling of the ankles
    • Blue lips or skin.
  • Weight loss drugs related to diethylpropion have caused problems with heart valves, especially when taken at high doses or for prolonged periods of time. Diethylpropion is not recommended for people with a heart murmur or heart valve problems.
  • Diethylpropion is chemically similar to amphetamines, which are often abused. Taking the medication for a long time can lead to dependence. Because diethylpropion is often abused, there are special rules for prescribing and dispensing it.
  • Check with your healthcare provider before stopping diethylpropion, as withdrawal symptoms (such as hallucinations) are possible, especially if you have been taking the drug for a long time.
  • Diethylpropion can increase your heart rate and blood pressure. This can cause problems, especially if you already have high blood pressure or heart problems.
  • The medication can make glaucoma worse. Check with your healthcare provider before taking diethylpropion if you have this condition.
  • Before you take diethylpropion, your healthcare provider should make sure that your obesity is not caused by a medical problem.
  • For people with seizures or epilepsy, diethylpropion may increase the risk of seizures. If you have a history of seizures, check with your healthcare provider before taking this medication.
  • The medication may affect your ability to perform tasks that require complete concentration, such as driving, operating machinery, or piloting an airplane, especially during the first few weeks of treatment. You should use caution when performing these activities until you know exactly how diethylpropion affects you.
  • Diethylpropion can interact with a number of different medications (see Drug Interactions With Diethylpropion).
  • Diethylpropion is considered a pregnancy Category B medication. This means that it is probably safe for use during pregnancy (see Tenuate and Pregnancy).
  • Diethylpropion passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Tenuate and Breastfeeding).
Last reviewed by: Kristi Monson, PharmD
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