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Diflucan Drug Interactions

Interactions With Diflucan Explained

The following sections explain in detail the potentially negative interactions that can occur when Diflucan is combined with any of the drugs listed above.
Certain Benzodiazepines
Diflucan may increase the level of many benzodiazepines in the blood, possibly increasing the risk of serious side effects. Your healthcare provider may decide to lower your benzodiazepine dosage or even avoid this combination altogether in some situations.
Cisapride
Cisapride and Diflucan should never be taken together, due to the risk of a dangerous irregular heart rhythm known as torsade de pointes.
Conivaptan
The combination of conivaptan and Diflucan should be avoided, since Diflucan may substantially increase the level of conivaptan in the blood.
Cyclosporine
Diflucan increases the level of cyclosporine in the bloodstream. If you must take these medications together, your healthcare provider should monitor your cyclosporine levels and adjust your dosage as necessary.
Dofetilide
In general, azole antifungals like Diflucan should not be combined with dofetilide, as this combination may result in increased levels of dofetilide in the blood.
Nilotinib
Combining nilotinib with Diflucan may increase the risk of a dangerous irregular heart rhythm (arrhythmia). In most cases, these medications should not be taken together.
Phenytoin
Diflucan increases the level of phenytoin in the bloodstream. If you take these medications together, your healthcare provider should monitor your phenytoin levels and adjust your dosage as necessary.
Last reviewed by: Kristi Monson, PharmD
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