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Diflucan Drug Interactions

Pimozide
Combining pimozide with Diflucan may increase the risk of a dangerous irregular heart rhythm (arrhythmia). In general, these medications should not be taken together.
Quinidine
Diflucan may increase the level of quinidine in the blood, perhaps increasing the risk of dangerous side effects. If you must take these medications together, your healthcare provider should monitor you closely and adjust your quinidine dosage as necessary.
Quinine
Combining quinine with Diflucan may increase the risk of a dangerous irregular heart rhythm (arrhythmia). It is generally recommended to avoid combining these medications.
Ranolazine
In general, azole antifungals like Diflucan should not be taken with ranolazine, as this combination may result in increased levels of ranolazine in the blood.
Rifabutin
Combining rifabutin and Diflucan can increase the level of rifabutin in the blood, decrease the level of Diflucan in the blood, and increase the risk of inflammation of the middle layer of the eye (uveitis).
Rifampin
Rifampin decreases the level of Diflucan in the blood, potentially making it less effective. In some situations, your healthcare provider may decide to recommend a higher Diflucan dosage to account for this drug interaction.
Sulfonylureas
Diflucan may increase the level of sulfonylurea medications in the bloodstream and could, therefore, cause dangerously low blood sugar (hypoglycemia). If you take these medications together, you must monitor your blood sugar more frequently and your healthcare provider may need to adjust the dosage of your sulfonylurea.
Tacrolimus
Diflucan may increase the level of tacrolimus in the blood, and taking these medications together may increase the risk of kidney damage. Check with your healthcare provider before combining these medications.
Last reviewed by: Kristi Monson, PharmD
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