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Diflucan Warnings and Precautions

Before you take Diflucan, warnings and precautions for the drug should be reviewed in order to help minimize risks and ensure safe treatment. Rare cases of liver damage and certain arrhythmias have been reported with this medication, usually in people with serious underlying conditions. Therefore, it is important that you inform your healthcare provider about all existing medical conditions you have before starting treatment.

What Should I Tell My Healthcare Provider Before Taking Diflucan?

You should talk with your healthcare provider prior to taking Diflucan® (fluconazole) if you have:
  • Liver disease, such as liver failure, hepatitis, or cirrhosis
  • Heart disease
  • An irregular heart rhythm
  • Long QT syndrome
  • An electrolyte imbalance
  • Any other allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Diflucan Warnings and Precautions

Some warnings and precautions to be aware of prior to taking Diflucan include the following:
  • Rare cases of liver damage (sometimes fatal) have been reported with Diflucan, usually in people with serious underlying medical conditions. Let your healthcare provider know right away if you develop signs of liver damage, such as:
    • Yellow eyes or skin (jaundice)
    • Upper-right abdominal pain (stomach pain)
    • Dark urine
    • Elevated liver enzymes (found using a standard blood test).
  • This medicine can cause severe, sometimes fatal, skin rashes. If you develop a rash while taking Diflucan, your healthcare provider should monitor you to make sure serious problems do not result.
  • In rare cases, Diflucan can cause severe, anaphylactic allergic reactions.
  • Rare cases of certain irregular heart rhythms (known as QT prolongation and torsades de pointes) have been reported with Diflucan, usually in people who were already seriously ill and who also had other risk factors for such arrhythmias, such as heart disease or electrolyte imbalances.
  • Although a single oral dose of Diflucan is convenient and effective for treating vaginal yeast infections, it should be noted that studies suggest that this medication is more likely to cause side effects compared to the standard vaginal treatments, such as yeast infection creams.
  • Diflucan can interact with other medications (see Diflucan Drug Interactions).
  • Diflucan is considered a pregnancy Category C or D medication, depending on the use. This means that it might not be safe for use during pregnancy, although the full risks are not known. Talk to your healthcare provider about the risks and benefits of using this drug when pregnant (see Diflucan and Pregnancy for more information).
  • Diflucan passes through breast milk. Therefore, if you are breastfeeding or plan to start, be sure to talk with your healthcare provider about using this medicine (see Diflucan and Breastfeeding for more information).
Last reviewed by: Kristi Monson, PharmD
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