Diflucan is commonly prescribed to treat various types of fungal infections, including yeast infections and thrush. It is also approved to prevent yeast infections in people undergoing bone marrow transplantations. The medication comes in tablet, liquid suspension, and injectable form. Some of the most commonly reported side effects include nausea, headache, and abdominal pain.

What Is Diflucan?

Diflucan® (fluconazole) is a prescription antifungal medication. It is approved to treat a variety of different fungal infections, such as yeast infections and thrush. The drug can also be used to prevent yeast infections in people undergoing bone marrow transplantations.
(Click Diflucan Uses for more information, including possible off-label uses.)

Who Makes This Medication?

Brand-name Diflucan is made by Pfizer, Inc. Generic versions are made by various manufacturers.

How Does It Work?

Diflucan belongs to a group of medications known commonly as "azole" antifungals. It works by inhibiting an enzyme that is used by fungal cells to make ergosterol, an important component of the fungal cell membrane. As a result, there is not enough ergosterol (and too much of the compounds that are normally used to make it), and fungal growth is inhibited.

When and How to Take Diflucan

Some general considerations for those taking Diflucan include the following:
  • Diflucan comes in tablet, suspension (oral liquid), and injectable form.
  • Unlike most other yeast infection medications, Diflucan is not used vaginally. It works through the bloodstream to treat yeast infections.
  • You can take a dose either with or without food and at any time of the day.
  • Be sure to shake the oral suspension form well before each dose.
  • For the medication to work properly, it must be taken as prescribed.
Last reviewed by: Kristi Monson, PharmD
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