Dinoprostone Vaginal Gel

Drug Interactions

Dinoprostone vaginal gel is unlikely to react with most other medicines (see Drug Interactions With Dinoprostone Vaginal Gel).

What If I Overdose on This Medicine?

An overdose of this medication could cause increased uterine contractions and fetal distress. If you use too much, seek immediate medical attention.
(Click Prepidil Overdose for more information.)

What If I Miss a Dose of Dinoprostone Vaginal Gel?

Because this medication is given by your healthcare provider when you are near the time of delivery (see Prepidil and Pregnancy), it is unlikely that you will miss a dose.

How Does It Work?

Dinoprostone vaginal gel is a manufactured (synthetic) version of a hormone in the body known as prostaglandin E2. Prostaglandin E2 is naturally secreted by the fetus and placenta during pregnancy and plays an important role in the steps leading to labor. Importantly, the hormone is involved in cervical ripening, which is when the cervix softens and relaxes to allow passage of the baby during birth.

When and How to Use Dinoprostone Vaginal Gel

Some general considerations to keep in mind during treatment with dinoprostone vaginal gel include the following:
  • This medication comes in gel form. The gel is inserted into the cervix using a syringe.
  • Dinoprostone vaginal gel should only be inserted by a trained medical provider in a hospital setting.
  • After the gel is inserted, you will need to remain lying down for at least 15 to 30 minutes to prevent the medication from leaking out.
  • For dinoprostone vaginal gel to work properly, it must be used as prescribed.
Last reviewed by: Kristi Monson, PharmD
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