Precautions and Warnings With Dinoprostone Vaginal Gel

Women who receive dinoprostone vaginal gel should be aware that this medicine can increase the risk for potential complications, such as abnormal uterine contractions and dangerous bleeding after delivery. Other precautions for safely using dinoprostone vaginal gel include warnings against using this drug in women who have had a major surgery on their uterus or who have had unexplained vaginal bleeding during their pregnancy.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to receiving dinoprostone vaginal gel (Prepidil®) if you have:
  • Had vaginal bleeding during your pregnancy
  • Had a cesarean section (C-section) in the past
  • Had difficult labor or delivery in the past
  • Had major surgery on your uterus
  • Any disease or condition that affects your uterus
  • Given birth six or more times when the baby was not in the usual position (head-down)
  • Genital herpes
  • Glaucoma or increased pressure in your eye(s)
  • Asthma or have ever had asthma, even as a child
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • Any allergies, including to foods, dyes, or preservatives.
In addition, let your healthcare provider know if you are breastfeeding and tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
Last reviewed by: Kristi Monson, PharmD
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