Dysport and Pregnancy

In clinical studies on pregnant rats, Dysport (abobotulinumtoxinA) increased the risk of stillbirth and miscarriage. However, no studies have been performed on pregnant women using this product, so it is unclear if the same problems would occur. Your healthcare provider can provide information about the benefits and risks of using this medication in your particular situation.

Is Dysport Safe During Pregnancy?

Dysport® (abobotulinumtoxinA) is a prescription injection approved for both cosmetic and medical purposes. Based on the results of animal studies, Dysport may not be safe for use during pregnancy.

What Is Pregnancy Category C?

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category C is given to medicines that have not been studied in pregnant humans but that do appear to cause harm to the fetus in animal studies.
In addition, medicines that have not been studied in any pregnant women or animals are automatically given a pregnancy Category C rating.
When given to pregnant rats, Dysport increased the risk of miscarriages and stillbirths. It is unknown whether similar problems would occur with humans as well, as the drug has not been studied in pregnant women.
However, there have been cases when pregnant women have accidentally been exposed to botulinum toxin, whether through food poisoning or other accidental exposures. These cases suggest that botulinum toxin does not cross the placenta to the baby.
There may be circumstances when the risks of using Dysport in pregnancy are outweighed by the possible benefits. However, cosmetic use of this medicine by pregnant women is generally not recommended.

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Last reviewed by: Kristi Monson, PharmD
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