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Drug Interactions With Esterified Estrogens

Esterified Estrogens Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when esterified estrogens is combined with any of the drugs listed above.
Barbiturate Medications
Barbiturates may cause your body to metabolize the hormones in esterified estrogens too rapidly, leading to low levels of esterified estrogens in the body. This can make esterified estrogens less effective, but it is not a serious drug interaction.
Certain Antifungals or Antibiotics
Some antibiotic or antifungal medications may decrease the ability of your liver to metabolize esterified estrogens, leading to high levels of esterified estrogens in the body. This may increase the risk of esterified estrogens side effects. Check with your healthcare provider before combining esterified estrogens with certain antibiotics or antifungals.
Certain Seizure Medications
Some seizure medications may cause your body to metabolize the hormones in esterified estrogens too quickly, leading to low levels of esterified estrogens in the body. Although this can make esterified estrogens less effective, it is not a dangerous drug interaction.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Esterified estrogens may increase the level of cyclosporine in your blood, increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower cyclosporine dose, or you may need to switch to one of the many esterified estrogens alternatives.
Grapefruit Juice
Grapefruit juice may decrease the ability of your liver to metabolize esterified estrogens, leading to high levels of esterified estrogens in the body. This may increase the risk of esterified estrogens side effects.
Last reviewed by: Kristi Monson, PharmD
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