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Drug Interactions With Esterified Estrogens

Hypothyroidism Medications
If you take medications for an underactive thyroid (hypothyroidism) together with esterified estrogens, your healthcare provider may need to increase the dose of your thyroid medication. Your healthcare provider should monitor you and make any necessary adjustments.
Protease Inhibitors
Protease inhibitors may decrease the ability of your liver to metabolize esterified estrogens, leading to high levels of esterified estrogens in the body. This may increase the risk of esterified estrogens side effects. Check with your healthcare provider before combining esterified estrogens with a protease inhibitor.
Rifamycin Antibiotics
Rifamycin antibiotics may cause your body to metabolize the hormones in esterified estrogens too quickly, leading to low levels of esterified estrogens in the body. Although this can make esterified estrogens less effective, it is not a dangerous drug interaction.
St. John's Wort
St. John's wort (a commonly used herbal supplement) may cause your body to metabolize the hormones in esterified estrogens too quickly, leading to low levels of esterified estrogens in the body. Although this can make esterified estrogens less effective, it is not a dangerous drug interaction.

Final Thoughts on Esterified Estrogens Drug Interactions

It is possible that not every drug interaction with esterified estrogens was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the esterified estrogens drug interactions that may apply to you.
Last reviewed by: Kristi Monson, PharmD
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