Drug Interactions With Esterified Estrogens

A number of medications could potentially cause drug interactions with esterified estrogens, including cyclosporine, certain antifungals or antibiotics, St. John's wort, and hypothyroidism medicines. These esterified estrogens drug interactions can affect the level of the estrogen medication in your blood, which may increase your risk for developing side effects or decrease the effectiveness of the medicines.

An Introduction to Esterified Estrogens Drug Interactions

Esterified estrogens (Menest®) can potentially interact with various other medications. While some of these interactions can be serious, some are rather minor. Some of the medicines that may lead to esterified estrogens interactions include:
  • Barbiturates, including (but not limited to):
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
  • Certain antifungal medications or antibiotics, such as:


    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)
  • Certain seizure medications, such as:



  • Protease inhibitor HIV medications, such as:


Last reviewed by: Kristi Monson, PharmD
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