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Esterified Estrogens Dosage

Esterified Estrogens Dosing for Low Estrogen in Younger Women

The recommended esterified estrogens dose for estrogen replacement in younger women who have low estrogen levels (due to a variety of causes) is 1.25 to 7.5 mg once daily, depending on the cause and the severity of estrogen deficiency. Your healthcare provider may increase or decrease your dose as necessary.
For these uses, esterified estrogens should be given cyclically (such as three weeks on with one week off or 20 days on with 10 days off). This will help mimic the natural hormonal changes that occur with the menstrual cycle and will usually cause regular monthly periods.

Esterified Estrogens Dosing for Cancer

For relieving symptoms of breast cancer that has spread throughout the body (in both men and women), the recommended esterified estrogens dose is very high -- 10 mg three times daily for at least three months. For relieving symptoms of prostate cancer, the recommended dose is 1.25 to 2.5 mg three times daily.

General Information on Dosing With Esterified Estrogens

Some considerations for people using esterified estrogens include the following:
  • Esterified estrogens comes in tablet form. It is taken by mouth once a day.
  • You can take esterified estrogens with food or on an empty stomach. If the drug bothers your stomach, try taking it with food (since some women find estrogens to be irritating to the stomach).
  • Esterified estrogens is usually taken cyclically (with periodic breaks every once in a while), unless you are taking it for relieving cancer symptoms, in which case it is usually taken continuously (every single day, with no breaks).
  • It does not matter what time of day you take esterified estrogens, although it is best to take it at the same time each day.
  • For the medication to work properly, it must be taken as prescribed.
  • If you are unsure about anything related to your esterified estrogens dosage, please talk to your doctor, nurse, or pharmacist.
Last reviewed by: Kristi Monson, PharmD
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