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Esterified Estrogens Dosage

The recommended esterified estrogens dosage for treating most menopause symptoms is 1.25 mg once daily. For relieving breast cancer symptoms, the dosage is high -- 10 mg three times daily for at least three months. For estrogen replacement in younger women with low estrogen levels, the usual dose is 1.25 to 7.5 mg once daily, depending on the cause and severity of estrogen deficiency.

Esterified Estrogens Dosage: An Introduction

The dose of esterified estrogens (Menest®) that your healthcare provider recommends will vary, depending on a number of factors, including:
  • The medical condition being treated
  • How you respond to esterified estrogens
  • Whether you have had a hysterectomy
  • Other medical conditions you may have.
As always, do not adjust your esterified estrogens dose unless your healthcare provider specifically instructs you to do so.

Esterified Estrogens Dosing for Menopause

When using esterified estrogens for menopausal symptoms, it is typically recommended to take the lowest effective dose for the shortest possible period of time. However, the most effective dose (and how long it should be taken) can vary considerably from one woman to the next. For most women with hot flashes or night sweats, the recommended starting esterified estrogens dose is 1.25 mg once daily. For women experiencing vaginal menopause symptoms, a lower dose (esterified estrogens 0.3 to 1.25 mg once daily) may be sufficient. If necessary, your healthcare provider may increase or decrease your dose.
It is recommended that esterified estrogens be taken cyclically (such as three weeks on and one week off). Taking it cyclically can help promote regular, menstrual-like bleeding (and decrease breakthrough bleeding), especially in younger women. Some healthcare providers may also recommend continuous use of esterified estrogens (every single day without any breaks). Taking it continuously can result in a complete absence of bleeding (especially in older women), a side effect that many women desire.
If you still have a uterus, you must take esterified estrogens with a progestin hormone in order to reduce the risk of precancerous and cancerous uterine changes. The progestin can be taken every day or for just a certain part of the cycle (often the last half of each cycle). If you have had a hysterectomy, you do not have to take progesterone along with esterified estrogens.
Last reviewed by: Kristi Monson, PharmD
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