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Drug Interactions With Estradiol Cypionate

Rifamycin Antibiotics
Rifamycin antibiotics may cause your body to metabolize the hormones in estradiol cypionate too quickly, leading to low levels of estradiol cypionate in the body. Although this can make estradiol cypionate less effective, it is not a dangerous drug interaction.
St. John's Wort
St. John's wort (a commonly used herbal supplement) may cause your body to metabolize the hormones in estradiol cypionate too quickly, leading to low levels of estradiol cypionate in the body. Although this can make estradiol cypionate less effective, it is not a dangerous drug interaction.
Thyroid Replacement Medications
If you take medications for an underactive thyroid (hypothyroidism) and estradiol cypionate together, your healthcare provider may need to increase the dose of your thyroid medication. Your healthcare provider should monitor you and make any necessary adjustments.

Final Thoughts on Drug Interactions With Estradiol Cypionate

It is possible that not every drug interaction with estradiol cypionate was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the estradiol cypionate drug interactions that may apply to you.
Last reviewed by: Kristi Monson, PharmD
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