Drug Interactions With Estradiol Cypionate

To avoid possible drug interactions with estradiol cypionate, talk to your healthcare provider about any other medications you are taking before starting treatment. Drug interactions may occur if estradiol cypionate is combined with medications such as seizure medications, thyroid medicines, and antibiotics. Some of these estradiol cypionate drug interactions can affect the way your body metabolizes these medicines, possibly increasing your risk of side effects.

An Introduction to Drug Interactions With Estradiol Cypionate

Even though estradiol cypionate (Depo®-Estradiol) is not taken by mouth, it has the potential to interact with numerous other medications. Some of the medicines that may lead to estradiol cypionate interactions include:
  • Barbiturates, including (but not limited to):


    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®
  • Certain antifungal medications or antibiotics, such as:


    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®
  • Certain seizure medications, such as:



  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
  • St. John's wort (Hypericum perforatum), an herbal supplement
  • Thyroid replacement medications, including:


Last reviewed by: Kristi Monson, PharmD
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