Estradiol Cypionate Dosage

The estradiol cypionate dosage you are prescribed will be based on several factors, such as how you respond to the drug and other medical conditions you have. Estradiol cypionate comes in the form of an injection that is taken every three to four weeks. For women with menopausal symptoms, this dose generally ranges from 1 mg to 5 mg.

Estradiol Cypionate Dosage: An Introduction

The dose of estradiol cypionate (Depo®-Estradiol) your healthcare provider recommends will vary, depending on a number of factors, including:
  • The medical condition being treated
  • How you respond to estradiol cypionate
  • Other medical conditions you may have.
As always, do not adjust your estradiol cypionate dose unless your healthcare provider specifically instructs you to do so.

Estradiol Cypionate Dosing for Menopause Symptoms

When treating menopausal symptoms, it is typically recommended that hormone replacement therapy (including estradiol cypionate) be taken at the lowest effective dose for the shortest possible period of time. However, the most effective dose (and how long it should be taken) can vary considerably from one woman to the next.
The recommended estradiol cypionate dose is 1 mg to 5 mg injected once every three to four weeks. If you still have a uterus (if you have not had a hysterectomy), it is recommended that you take a progestin medication along with estradiol cypionate, in order to help prevent cancer of the lining of the uterus.

Estradiol Cypionate Dosing for Low Estrogen Levels in Younger Women

For treating low estrogen levels in premenopausal women, the recommended estradiol cypionate dose is 1.5 mg to 2 mg injected once a month.

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Last reviewed by: Kristi Monson, PharmD
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