Estradiol Cypionate

How Should Estradiol Cypionate Be Stored?

Estradiol cypionate should be stored at room temperature, away from moisture and heat. Keep this and all other medications out of the reach of children.

What If I Miss a Dose?

If you are late for a dose of estradiol cypionate, simply contact your healthcare provider to schedule your next injection as soon as possible. You may experience an increase in menopause symptoms, but no serious problems should occur.

How Does Estradiol Cypionate Work?

Estradiol cypionate contains estradiol, a hormone that is the predominant estrogen in premenopausal women. It helps to relieve menopausal symptoms by replacing the estrogen that the ovaries no longer produce.
Estradiol cypionate is formulated in oil to make the injection long-acting.

When and How to Use This Medication

Some general considerations to keep in mind during treatment with estradiol cypionate include the following:
  • Estradiol cypionate is injected into a muscle every three to four weeks
  • Usually, your healthcare provider will inject estradiol cypionate for you
  • For the medication to work properly, it must be taken as prescribed.

Who Makes Estradiol Cypionate?

Estradiol cypionate is made by Pfizer, Inc. It is sold under the brand name Depo-Estradiol. Estradiol cypionate is also available in generic form (see Generic Depo-Estradiol for more information), which is manufactured by Consolidated Midland Corporation.

Available Strengths

Estradiol cypionate comes in a 5-mL vial, with 5 mg of estradiol cypionate per mL.
Last reviewed by: Kristi Monson, PharmD
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