Estradiol Cypionate

Estradiol cypionate is a prescription medication approved to treat menopausal symptoms and estrogen deficiency. This medication contains an estrogen hormone and works by replacing the estrogen the ovaries no longer produce. Estradiol cypionate comes in the form of an injection and is taken every three to four weeks. Possible side effects of the drug include breast pain, nausea, and headaches.

Estradiol Cypionate for Menopause

What Is Estradiol Cypionate?

Estradiol cypionate (Depo^®-Estradiol) is a prescription hormone replacement medication that contains estrogen. It comes as a long-acting injection that is injected into a muscle every three to four weeks. Estradiol cypionate is approved for the following uses:

Treating menopausal symptoms, such as hot flashes or night sweats
Replacing hormones in younger women whose ovaries do not produce enough estrogen (or who have had their ovaries removed).

(Click What Is Estradiol Cypionate Used For? for more information on what estradiol cypionate is used for, including possible off-label uses.)

Side Effects of Estradiol Cypionate

As with any medicine, estradiol cypionate can cause side effects. However, not everyone who uses the medication will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are easily treated by you or your healthcare provider. Serious side effects are less common.

Common side effects of estrogen medications such as estradiol cypionate include, but are not limited to:

Nausea and vomiting
Breast pain
Headaches
Abdominal pain (stomach pain)
Vaginal bleeding.

(Click Side Effects of Estradiol Cypionate to learn more, including potentially serious side effects that you should report immediately to your healthcare provider.)

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