Precautions and Warnings With Estradiol Cypionate

It is important to talk to your healthcare provider about the precautions and warnings with estradiol cypionate before starting the medication. For instance, you may not be able to safely use estradiol cypionate if you have certain health conditions (such as endometriosis, diabetes, or asthma), as estradiol cypionate can make some conditions worse. Estradiol cypionate warnings and precautions also include potential drug interactions and allergic reactions.

Estradiol Cypionate for Menopause

Estradiol Cypionate: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using estradiol cypionate (Depo^®-Estradiol) if you have:

Heart disease or heart problems of any kind
Cancer (or a history of cancer) of any kind
Had a heart attack, blood clot, or stroke
Unexplained abnormal vaginal bleeding
High blood pressure, high cholesterol, or high triglycerides
Gallbladder disease
Diabetes
Liver disease, such as liver failure, cirrhosis, hepatitis, or liver tumors
Asthma
Porphyria (a condition involving problems with certain enzymes in the body)
Seizures or epilepsy
Had yellowing of the whites of the eyes or skin (jaundice) during a prior pregnancy or estrogen use
Systemic lupus erythematosus (SLE, or lupus)
Migraine headaches
Hepatic hemangioma (a kind of liver tumor)
Kidney disease, including kidney failure (renal failure)
An underactive thyroid (hypothyroidism)
Endometriosis
Any allergies, including allergies to drugs, foods, preservatives, or dyes.

Also, let your healthcare provider know if you:

Are pregnant or thinking of becoming pregnant
Are breastfeeding
Have an upcoming surgery
Smoke cigarettes.

Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

(Precautions and Warnings With Estradiol Cypionate Continued: Page 2)