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Side Effects of Estradiol Cypionate

Common Side Effects of Estradiol Cypionate

Common side effects of estrogens, such as estradiol cypionate, include (but are not limited to):
  • Breast tenderness
  • Headaches
  • Irregular vaginal bleeding or spotting
  • Abdominal (stomach) cramps or bloating
  • Vaginal yeast infections
  • Nausea and vomiting
  • Hair loss
  • High blood pressure (hypertension)
  • High blood sugar (hyperglycemia)
  • Fluid retention
  • Enlargement of benign tumors of the uterus (uterine fibroids).

Final Thoughts on Side Effects of Estradiol Cypionate

It is possible that you may experience some or none of the estradiol cypionate side effects listed in this article. Unfortunately, it can be difficult to tell whether any particular side effect is caused by estradiol cypionate or by other factors. Therefore, make sure to let your healthcare provider know if you develop any side effects while taking estradiol cypionate, or if something "just does not seem right." While it may not be a side effect of the medication, your healthcare provider will be able to diagnose and treat the problem.
Last reviewed by: Kristi Monson, PharmD
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