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Side Effects of Estradiol Cypionate

In most cases, women tolerate estradiol cypionate well and do not experience any serious side effects. Estradiol cypionate can cause problems, however, such as breast tenderness, headaches, and irregular vaginal bleeding. These side effects are typically minor and easily treated. However, you should notify your healthcare provider immediately if you develop more serious side effects of estradiol cypionate, such as chest pain, vision changes, or migraines.

An Introduction to Side Effects of Estradiol Cypionate

As with any medicine, estradiol cypionate (Depo®-Estradiol) can cause side effects. However, not everyone who takes the medication will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with estradiol cypionate. Your healthcare provider can discuss a more complete list of estradiol cypionate side effects with you.)

Serious Side Effects of Estradiol Cypionate

Some side effects of estrogens (such as estradiol cypionate) are rare, but are serious enough to mention. These side effects include:
Because of the possibility of these serious side effects, there are a few symptoms that you should watch out for (and should report to your healthcare provider immediately). These include, but are not limited to:
  • Breast lumps or other unusual breast changes
  • Heavy vaginal bleeding or unexpected vaginal bleeding
  • Signs of a blood clot in the leg, such as pain in the calf, leg cramps, and leg or foot swelling
  • Signs of a blood clot in the lung, such as shortness of breath, sharp chest pain, or coughing up blood
  • Signs of a stroke, such as vision or speech changes, weakness or numbness in an arm or leg, and a severe headache
  • Chest pain or heaviness, which may be signs of a heart attack
  • Sudden loss of vision or vision changes, which can be a sign of a blood clot in the eye
  • Signs of liver damage, such as yellowing of the whites of the eyes or skin (jaundice), dark urine, and upper right abdominal pain (stomach pain)
  • Migraines (or changes in your migraines, if you have had them before)
  • Signs of an allergic reaction, including an unexplained rash, hives, itching, unexplained swelling, wheezing, or difficulty breathing or swallowing.
Last reviewed by: Kristi Monson, PharmD
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