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What Is Estradiol Cypionate Used For?

There are several estradiol cypionate uses, such as treating certain menopausal symptoms (including hot flashes and night sweats) and replacing hormones in younger women whose ovaries do not produce enough estrogen. On occasion, healthcare provider may also prescribe estradiol cypionate for other uses. Estradiol cypionate can be used "off-label" for men who are going through a sex change.

What Is Estradiol Cypionate Used For?

Estradiol cypionate (Depo®-Estradiol) is a prescription medication that contains an estrogen hormone. It is approved for the following uses:
  • Treatment of menopausal symptoms, such as hot flashes and night sweats
  • Treatment of hormone deficiency in younger women whose ovaries do not produce enough estrogen (or who have had their ovaries removed).

Estradiol Cypionate Use for Menopause

Menopause is a normal change in a woman's life when she stops having her period. Technically, a woman has reached menopause when she has not had a period for 12 months in a row and there are no other causes for this change. Menopause symptoms include:
  • Hot flashes (hot flushes)
  • Night sweats and sleeping problems (including insomnia)
  • Vaginal changes, such as dryness or irritation
  • Changes in your period, including abnormal bleeding or "spotting"
  • Thinning and weakening of your bones
  • Problems with concentration or memory
  • Less interest in sex and changes in sexual response
  • Mood changes
  • Urinary problems
  • Weight gain or an increase in body fat around your waist
  • Hair thinning or loss.
For some women, these symptoms are quite severe, and some form of menopause relief may be necessary. This may include medications, natural menopause relief remedies, or non-medical ways to deal with the symptoms. Estradiol cypionate is approved to treat moderate to severe vasomotor symptoms, which include hot flashes and night sweats (but not other kinds of menopause symptoms).
For menopause treatment, estradiol cypionate should be used at the lowest effective dose for the shortest period necessary.
Last reviewed by: Kristi Monson, PharmD
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