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Drug Interactions With Estradiol Vaginal Cream

Estradiol Vaginal Cream Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when estradiol vaginal cream is combined with any of the drugs listed above.
Barbiturate Medications
Barbiturates may cause your liver to metabolize the hormones in estradiol vaginal cream too quickly, leading to low levels of estradiol vaginal cream in the body. Because estradiol vaginal cream acts directly on the vaginal tissues and is absorbed into the bloodstream without passing through the liver first (which happens with oral medications), this interaction is probably not significant.
Certain Antibiotics or Antifungals
Some antibiotic or antifungal medications may decrease the ability of your liver to metabolize estradiol vaginal cream, leading to high levels of estradiol vaginal cream in the body. This may increase the risk of estradiol vaginal cream side effects. Check with your healthcare provider before combining estradiol vaginal cream with certain antibiotics or antifungals.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Estradiol vaginal cream may increase the level of cyclosporine in your blood, increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower cyclosporine dose, or you may need to switch to one of the many estradiol vaginal cream alternatives.
Grapefruit Juice
Grapefruit juice may decrease the ability of your body to metabolize estradiol vaginal cream, leading to high levels of estradiol vaginal cream in the body. This may increase the risk of estradiol vaginal cream side effects.
Protease Inhibitors
Protease inhibitors may decrease the ability of your liver to metabolize estradiol vaginal cream, leading to high levels of estradiol vaginal cream in the body. This may increase the risk of estradiol vaginal cream side effects. Check with your healthcare provider before combining estradiol vaginal cream with a protease inhibitor.
Last reviewed by: Kristi Monson, PharmD
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