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Drug Interactions With Estradiol Vaginal Cream

Rifamycin Antibiotics
Rifamycin antibiotics may cause your liver to metabolize the hormones in estradiol vaginal cream too quickly, leading to low levels of estradiol vaginal cream in the body. Because estradiol vaginal cream acts directly on the vaginal tissues and is absorbed into the bloodstream without passing through the liver first (as happens with oral medications), this interaction is probably not significant.
Some Seizure Medications
Some seizure medications may cause your liver to metabolize the hormones in estradiol vaginal cream too quickly, leading to low levels of estradiol vaginal cream in the body. Because estradiol vaginal cream acts directly on the vaginal tissues and is absorbed into the bloodstream without passing through the liver first (as happens with oral medications), this interaction is probably not significant.
St. John's Wort
St. John's wort (a commonly used herbal supplement) may cause your liver to metabolize the hormones in estradiol vaginal cream too quickly, leading to low levels of estradiol vaginal cream in the body. Because estradiol vaginal cream acts directly on the vaginal tissues and is absorbed directly into the bloodstream without passing through the liver first (as happens with oral medications), this interaction is probably not significant.
Thyroid Medications
If you take medications for an underactive thyroid (hypothyroidism) together with estradiol vaginal cream, your healthcare provider may need to increase the dose of your thyroid medication. Your healthcare provider should monitor you and make any necessary adjustments.

Final Thoughts on Estradiol Vaginal Cream Drug Interactions

It is possible that not every drug interaction with estradiol vaginal cream was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the estradiol vaginal cream drug interactions that may apply to you.
Last reviewed by: Kristi Monson, PharmD
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