Drug Interactions With Estradiol Vaginal Cream

A number of medicines could cause drug interactions with estradiol vaginal cream, including certain antifungals or antibiotics, protease inhibitors, and thyroid medications. Some estradiol vaginal cream interactions can increase your risk of developing side effects, while others can cause your liver to metabolize the hormones in estradiol vaginal cream too quickly (leading to low levels of the drug in your body).

An Introduction to Estradiol Vaginal Cream Drug Interactions

Estradiol vaginal cream (Estrace® Vaginal Cream) can potentially interact with several medicines. Some of the medicines that may lead to estradiol vaginal cream interactions include:
  • Barbiturates, including, but not limited to:


    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)


  • Certain antifungals or antibiotics, including:


    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)


  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
  • Some seizure medications, such as:



Last reviewed by: Kristi Monson, PharmD
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