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Estradiol Vaginal Cream

How Does Estradiol Vaginal Cream Work?

Estradiol vaginal cream contains estradiol, the main estrogen hormone produced by the ovaries before menopause. It helps to relieve menopausal symptoms by replacing the estradiol that the ovaries no longer produce. It is a good alternative to hormone replacement therapy taken by mouth, especially in women who only have vaginal menopausal symptoms. It should be noted that a significant amount of estradiol vaginal cream is absorbed into the bloodstream, and many of the risks associated with oral estrogen hormone replacement therapy are expected to occur with estradiol vaginal cream as well.

When and How to Use Estradiol Vaginal Cream

Some general considerations for when and how to use estradiol vaginal cream include the following:
  • Estradiol vaginal cream comes in a tube, along with an applicator that can measure between 1 to 4 grams of the cream.
  • Your estradiol vaginal cream package comes with detailed instructions on how to use the cream using the enclosed applicator.
  • Estradiol vaginal cream is usually used daily to start, but most women can eventually cut back to just three times a week.
  • Many women find it easiest to use estradiol vaginal cream at night, just before bedtime, to help prevent it from leaking out of the vagina. However, you can use estradiol vaginal cream any time of the day -- whenever works best for you.
  • For the medication to work properly, it must be taken as prescribed.

Estradiol Vaginal Cream Dosing Information

The dose of estradiol vaginal cream that your healthcare provider recommends will vary, depending on a number of factors, including:
  • How you respond to estradiol vaginal cream
  • Other medical conditions you may have.
As always, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
(Click Estradiol Vaginal Cream Dosage for more information.)
Last reviewed by: Kristi Monson, PharmD
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