Precautions and Warnings With Estradiol Vaginal Cream

Who Should Not Use Estradiol Vaginal Cream?

You should not use estradiol vaginal cream if you:
  • Are allergic to estradiol vaginal cream, Estrace Vaginal Cream, or any of the inactive components used to make the medication. Your healthcare provider or pharmacist has a list of the inactive components.
  • Have a history of breast cancer.
  • Have any cancer that is sensitive to estrogen.
  • Have undiagnosed abnormal genital bleeding.
  • Have ever had a blood clot or pulmonary embolism (a blood clot in the lungs).
  • Have had a heart attack or stoke within the past year.
  • Have liver dysfunction or liver disease.
  • Are pregnant (or think you might be pregnant).

Estradiol Vaginal Cream Warnings and Precautions: Final Thoughts

There are a number of situations in which estradiol vaginal cream should not be used, along with several precautions and warnings people should be aware of before using this medication. However, it is possible that not all of the warnings or precautions were discussed in this article. Therefore, you should talk with your healthcare provider about the specific estradiol vaginal cream warnings and precautions that may apply to you.
Last reviewed by: Kristi Monson, PharmD
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