Precautions and Warnings With Estradiol Vaginal Cream

Make sure to talk to your healthcare provider about the precautions and warnings with estradiol vaginal cream to help ensure safe treatment. Certain women should not use the medication, including those who are pregnant, have liver disease, or have a history of breast cancer. It is also important to know that estradiol vaginal cream can increase the risk of dementia, breast cancer, and gallbladder disease.

 

Estradiol Vaginal Cream: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using estradiol vaginal cream (Estrace® Vaginal Cream) if you have:
 
  • Cancer (or if you have had cancer in the past)
  • Unexplained vaginal bleeding
  • High blood pressure (hypertension)
  • Had a blood clot
  • Had a heart attack or stroke
  • Heart disease
  • Liver disease, such as liver failure, cirrhosis, hepatitis, or liver tumors
  • Kidney disease, including kidney failure (renal failure)
  • Diabetes
  • Had yellowing of the whites of the eyes or skin (jaundice) during a prior pregnancy or estrogen use
  • Gallbladder disease
  • Congestive heart failure (CHF)
  • An underactive thyroid (hypothyroidism)
  • Low calcium levels in the blood (hypocalcemia)
  • Endometriosis
  • Any allergies, including allergies to drugs, foods, preservatives, or dyes.
     
Also, let your healthcare provider know if you:
 
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding
  • Have an upcoming surgery
  • Smoke cigarettes.
     
Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 
(Precautions and Warnings With Estradiol Vaginal Cream Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;