Precautions and Warnings With Estradiol Vaginal Cream

Make sure to talk to your healthcare provider about the precautions and warnings with estradiol vaginal cream to help ensure safe treatment. Certain women should not use the medication, including those who are pregnant, have liver disease, or have a history of breast cancer. It is also important to know that estradiol vaginal cream can increase the risk of dementia, breast cancer, and gallbladder disease.

Information on Estradiol Vaginal Cream

Estradiol Vaginal Cream: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using estradiol vaginal cream (Estrace^® Vaginal Cream) if you have:

Cancer (or if you have had cancer in the past)
Unexplained vaginal bleeding
High blood pressure (hypertension)
Had a blood clot
Had a heart attack or stroke
Heart disease
Liver disease, such as liver failure, cirrhosis, hepatitis, or liver tumors
Kidney disease, including kidney failure (renal failure)
Diabetes
Had yellowing of the whites of the eyes or skin (jaundice) during a prior pregnancy or estrogen use
Gallbladder disease
Congestive heart failure (CHF)
An underactive thyroid (hypothyroidism)
Low calcium levels in the blood (hypocalcemia)
Endometriosis
Any allergies, including allergies to drugs, foods, preservatives, or dyes.

Also, let your healthcare provider know if you:

Are pregnant or thinking of becoming pregnant
Are breastfeeding
Have an upcoming surgery
Smoke cigarettes.

Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

(Precautions and Warnings With Estradiol Vaginal Cream Continued: Page 2)