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Side Effects of Estradiol Vaginal Cream

Vaginal yeast infections, headaches, and nausea are some of the most common side effects reported with estrogen medications like estradiol vaginal cream. Side effects are generally mild, but some are more serious and may require immediate medical attention. Some of these rare but serious side effects of estradiol vaginal cream include dementia, blood clots, strokes, and allergic reactions.

An Introduction to Estradiol Vaginal Cream Side Effects

As with any medicine, estradiol vaginal cream (Estrace® Vaginal Cream) can cause side effects. However, not everyone who uses the medication will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with estradiol vaginal cream. Your healthcare provider can discuss a more complete list of estradiol vaginal cream side effects with you.)

Serious Side Effects Seen With Estradiol Vaginal Cream

Some side effects of estrogen medications, including estradiol vaginal cream, are rare but are serious enough to mention. These side effects include:
Because of the possibility of these serious side effects, there are a few symptoms you should watch for and report to your healthcare provider immediately. These include, but are not limited to:
  • Signs of a blood clot in the leg, such as pain in the calf, leg cramps, and leg or foot swelling
  • Signs of a blood clot in the lung, such as shortness of breath, sharp chest pain, or coughing up blood
  • Signs of a stroke, such as vision or speech changes, weakness or numbness in an arm or leg, and a severe headache
  • Signs of liver damage, such as yellowing of the whites of the eyes or skin (jaundice), dark urine, and upper right abdominal pain (stomach pain)
  • Migraines (or changes in your migraines, if you have had them before)
  • Breast lumps
  • Chest pain or heaviness, which may be signs of a heart attack
  • Sudden loss of vision or vision changes, which can be a sign of a blood clot in the eye
  • Heavy vaginal bleeding or unexpected vaginal bleeding
  • Signs of an allergic reaction, including an unexplained rash, hives, itching, unexplained swelling, wheezing, or difficulty breathing or swallowing.
Last reviewed by: Kristi Monson, PharmD
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