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Drug Interactions With Estradiol Vaginal Tablets

More Information on Interactions With Estradiol Vaginal Tablets

The following sections explain in detail the potentially negative interactions that can occur when estradiol vaginal tablets are combined with any of the drugs listed above.
Barbiturate Medications
Barbiturates may cause your body to metabolize the hormones in estradiol vaginal tablets more quickly than normal, possibly leading to low levels of these hormones in the body. Because estradiol vaginal tablets act directly on the vaginal tissues, this interaction is probably not significant.
Certain Antibiotics or Antifungals
Some antibiotic or antifungal medications may decrease your body's ability to metabolize estradiol vaginal tablets, possibly leading to higher-than-normal levels of medication in the body. This may increase the risk of side effects. Check with your healthcare provider before combining estradiol vaginal tablets with certain antibiotics or antifungals.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Estradiol vaginal tablets may increase the level of cyclosporine in your blood, possibly increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. You may need a lower cyclosporine dose, or you may need to switch to one of the many alternatives.
Grapefruit Juice
Grapefruit juice may decrease the ability of your body to metabolize estradiol vaginal tablets, possibly leading to higher-than-normal levels of medication in the body. This may increase the risk of side effects.
Protease Inhibitors
Protease inhibitors may decrease your body's ability to metabolize estradiol vaginal tablets, possibly leading to higher-than-normal levels of medication in the body. This may increase the risk of side effects. Check with your healthcare provider before combining these medications.
Last reviewed by: Kristi Monson, PharmD
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