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Drug Interactions With Estradiol Vaginal Tablets

Rifamycin Antibiotics
Rifamycin antibiotics may cause your body to metabolize the hormones in estradiol vaginal tablets too quickly, possibly leading to low levels of medication in the body. Because estradiol vaginal tablets act directly on the vaginal tissues, this interaction is probably not significant.
Some Seizure Medications
Some seizure medications may cause your body to metabolize the hormones in estradiol vaginal tablets too quickly, possibly leading to low levels of medication in the body. Because estradiol vaginal tablets act directly on the vaginal tissues, this interaction is probably not significant.
St. John's Wort
St. John's wort (a commonly used herbal supplement) may cause your body to metabolize the hormones in estradiol vaginal tablets too quickly, possibly leading to low levels of medication in the body. Because estradiol vaginal tablets act directly on the vaginal tissues, this interaction is probably not significant.
Thyroid Medications
If you take medications for an underactive thyroid (hypothyroidism) and estradiol vaginal tablets together, your healthcare provider may need to increase the dose of your thyroid medication. Your healthcare provider should monitor you and make any necessary dosing adjustments.

Final Thoughts on Drug Interactions With Estradiol Vaginal Tablets

It is possible that not all drug interactions with estradiol vaginal tablets were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific drug interactions that may apply to you.
Last reviewed by: Kristi Monson, PharmD
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