An Introduction to Drug Interactions With Estradiol Vaginal Tablets
Estradiol vaginal tablets (
Vagifem®) are not likely to interact with other medications, because they are taken vaginally at a low dose and little of the medication reaches the bloodstream and the liver (where many drug interactions occur).
However, because no drug-interaction studies have been done with estradiol vaginal tablets, it is possible (although not likely) that any of the usual drug interactions with estrogen medications may also occur with estradiol vaginal tablets. Some of the medicines that may lead to drug interactions with estradiol vaginal tablets include:
- Butalbital (Fioricet®, Fiorinal®)
- Pentobarbital (Nembutal®)
- Phenobarbital (Luminal®)
- Certain antifungals or antibiotics, such as:
- Rifamycin antibiotics, such as:
