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What Are Estradiol Vaginal Tablets Used For?

Estradiol vaginal tablets are used for treating vaginal dryness, burning, and itching that can be caused by menopause. These symptoms are typically caused by thinning of the vaginal tissues due to low estrogen levels after menopause. The tablets are specifically designed for women whose primary menopause symptoms are vaginal in nature. At this time, there are no off-label uses of estradiol vaginal tablets.

What Are Estradiol Vaginal Tablets Used For? -- An Overview

Estradiol vaginal tablets (Vagifem®) are a prescription hormone replacement therapy medication. The medication comes in the form of small tablets that are inserted vaginally using disposable, single-use applicators. Estradiol vaginal tablets are approved to treat vaginal inflammation caused by thinning of the vaginal tissues, usually the result of low estrogen levels after menopause. The tablets contain estradiol, the primary estrogen hormone in premenopausal women; they do not contain any progesterone hormones.

Why Are Estradiol Vaginal Tablets Used for Vaginal Symptoms?

Menopause is a normal change in a woman's life when she stops having her period. That's why some people call menopause "the change of life." A woman has reached menopause when she has not had a period for 12 months in a row and there are no other causes for this change. Menopause symptoms can affect the entire body, including the vagina. Vaginal menopause symptoms are usually related to thinning of the vaginal tissues and may include:
  • Burning or other pain
  • Dryness
  • Itching.
These symptoms occur due to low estradiol levels after menopause. Because estradiol vaginal tablets help replace some of the estradiol lost during menopause, they not only help relieve vaginal symptoms, but can also reduce thinning of the vaginal tissues.
For menopause treatment, estradiol vaginal tablets should be used at the lowest effective dose for the shortest period necessary. The tablets are ideal for women whose main menopause symptoms are vaginal in nature, as using the tablets (instead of taking the hormones by mouth) exposes the body to a lower dose of the hormones.
Last reviewed by: Kristi Monson, PharmD
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